About the lab head
Prof. Dr. Alexander S. Mosig
Alexander Mosig is a biochemist and cell biologist whose work is driven by the question, how the human immune system, and the innate immune system in particular, orchestrates its response to infection and inflammation. During his doctoral work he began using complex in vitro systems to study organ-specific immune responses, and his research has since centred on organ-on-chip models and the 3R principle of replacing, reducing and refining animal experiments.
He studied biochemistry and completed his doctorate on immune cells in vascular disease at Jena University Hospital, before turning to microphysiological models during his postdoctoral years. In 2017 he habilitated in biochemistry and cell biology at Friedrich Schiller University Jena with work on microphysiological systems of the liver and the blood-brain barrier. He heads the NAMIR research group at the Institute of Biochemistry II. In 2018 he co-founded Dynamic42, a spin-off that carries the organ-on-chip technology developed in Jena into industrial drug and safety testing.
His group studies the host-microbiota interface and the adaptive immune response to changes in the microbiota during infection and inflammation, with a particular focus on the plasticity of myeloid cells and the immunological niches shaped by microbes and their metabolites. Using primary human cells, adult stem cells and induced pluripotent stem cells, he models viral, bacterial, fungal and parasitic infection and inflammatory disease in the gut, lung and liver, work recognised among others by the 2017 research award of the German Federal Ministry of Food and Agriculture for 3R methods.
Full curriculum vitae →