Lung-on-chip publications

Publications

Lung-on-chip

Publications from our respiratory and alveolus work. Each entry includes a short summary of its content. The complete list of all papers is on the publications page.

Intestine-on-chip Lung-on-chip Liver-on-chip

Lung-on-chip systems for infection and inflammation research, platforms, applications, and future directions.

Koceva H, Mosig AS (2026)

An overview of lung-on-chip systems for infection and inflammation research, covering platforms, applications and future directions.

Generation of an induced pluripotent stem cell-derived alveolar type II in vitro model to study influenza A virus infection and drug treatments

Gauthier, L.*, Koceva, H.*, Bachelot, Y., Koutstaal, R., van Kasteren, P., Figge, M.T., Eggeling, C., Mosig, A.S. (2025). Advanced Healthcare Materials · DOI ↗

Generates alveolar type II cells from induced pluripotent stem cells to model influenza A virus infection and to test antiviral drug treatments.

Human induced pluripotent stem cell-based alveolus-on-chip model to study influenza virus A infection

Koceva, H., Mosig, A.S. (2025). In Influenza Virus, Methods and Protocols (Methods in Molecular Biology) · DOI ↗

A protocol chapter for a human iPSC-based alveolus-on-chip to study influenza A virus infection.

Deciphering respiratory viral infections by harnessing organ-on-chip technology to explore the gut-lung axis

Koceva, H., Amiratashani, M., Akbarimoghaddam, P., Hoffmann, B., Zhurgenbayeva, G., Gresnigt, M.S., Rossetto Marcelino, V., Eggeling, C., Figge, M.T., João Amorim, M., Mosig, A.S. (2025). Open Biology · DOI ↗

Reviews how organ-on-chip technology can dissect respiratory viral infections and the gut-lung axis that links intestinal and lung health.

Immunocompetent alveolus-on-chip model for studying alveolar mucosal immune responses

Koceva, H., Amiratashani, M., Rennert, K., Mosig, A.S. (2024). Journal of Visualized Experiments (JoVE), (207) · DOI ↗

A step-by-step protocol for the immunocompetent alveolus-on-chip used to study mucosal immune responses in the alveolus.

SARS-CoV-2 causes severe epithelial inflammation and barrier dysfunction

Deinhardt-Emmer, S., Böttcher, S., Häring, C., Giebeler, L., Henke, A., Zell, R., Jungwirth, J., Jordan, P.M., Werz, O., Hornung, F., Brandt, C., Marquet, M., Mosig, A.S., Pletz, M.W., Schacke, M., Rödel, J., Heller, R., Nietzsche, S., Löffler, B., Ehrhardt, C. (2021). Journal of Virology · DOI ↗

Shows that SARS-CoV-2 triggers severe epithelial inflammation and barrier dysfunction, relevant to the lung pathology of COVID-19.

Co-infection with Staphylococcus aureus after primary influenza virus infection leads to damage of the endothelium in a human alveolus-on-a-chip model

Deinhardt-Emmer, S., Rennert, K., Schicke, E., Cseresnyes, Z., Windolph, M., Nietzsche, S., Heller, R., Siwczak, F., Haupt, K.F., Carlstedt, S., Schacke, M., Figge, M.T., Ehrhardt, C., Löffler, B., Mosig, A.S. (2020). Biofabrication · DOI ↗

In a human alveolus-on-chip, a secondary Staphylococcus aureus infection after influenza damages the endothelial barrier, modelling post-viral bacterial superinfection.

Staphylococcus aureus lung infection results in down-regulation of surfactant protein-A mainly caused by pro-inflammatory macrophages

Schicke, E., Cseresnyes, Z., Rennert, K., Vau, V., Haupt, K.F., Hornung, F., Nietzsche, S., Siwczak, F., Schmidtke, M., Glück, B., Koch, M., Schacke, M., Heller, R., Mosig, A.S., Figge, M.T., Ehrhardt, C., Löffler, B., Deinhardt-Emmer, S. (2020). Microorganisms · DOI ↗

Shows that Staphylococcus aureus lung infection lowers surfactant protein-A, an effect driven mainly by pro-inflammatory macrophages.